Effect of red blood cell storage time in pediatric cardiac surgery patients: A subgroup analysis of a randomized controlled trial

ObjectiveThis study aimed to determine whether or not transfusion of fresh red blood cells (RBCs) reduced the incidence new progressive multiple organ dysfunction syndrome compared with standard-issue RBCs in pediatric patients undergoing cardiac surgery.MethodsPreplanned secondary analysis Age Blood Children Pediatric Intensive Care Unit study, an international randomized controlled trial. This included children enrolled trial and admitted a intensive care unit after surgery cardiopulmonary bypass. Patients were receive either (stored ≤7 days) RBCs. The primary outcome measure was syndrome, measured up 28 days postrandomization at discharge, death.ResultsOne hundred seventy-eight (median age, 0.6 years; interquartile range, 0.3-2.6 years) 89 group length storage, 5 days; 4-6 18 13-22 days). There no statistically significant differences between (43 out [48.3%]) groups (38 88 [43.2%]), relative risk 1.12 (95% CI, 0.81 1.54; P = .49) unadjusted absolute difference 5.1% −9.5% 19.8%; .49).ConclusionsIn neonates bypass, use did reduce A larger is needed confirm these results.